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In one 2023 study funded by Novo Nordisk, scientists found that participants without type 2 diabetes who took oral semaglutide every day for 68 weeks lost an average of 15 percent of their body weight
Moreover, Elkind-Hirsch et al

Badulescu S, Tabassum A, Le GH, Wong S, Phan L, Gill H, Llach CD, McIntyre RS, Rosenblat J, Mansur R (2024) Glucagon-like peptide 1 agonist and effects on reward behaviour: A systematic review

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Importantly, these differences were not large enough to change the half-life or overall clearance timeline of about five to seven weeks
