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Mobile phase A was composed of 0.1% formic acid in water and mobile phase B was composed of 0.1% formic acid in acetonitrile

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Regarding the latter resolution, this paper introduced the use of GLP-1RAsa drug class traditionally used in the treatment and management of T2DM and obesityas a potential avenue for the treatment of neurodegenerative diseases and neuropathologic conditions alike due to the drugs extensively cited neuroprotective effects

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Taken together, these methodological constraints mean that the robust and consistent epidemiological associations reported in this literature should be regarded as hypothesis-generating signals rather than definitive evidence of a causal neuroprotective effect