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There are also reports that maternal isolated hypothyroxinaemia (normal TSH concentration in conjunction with a low free T4) is associated with adverse metabolic parameters including increased maternal body mass index, higher fasting and postprandial glucose, higher HbA1c, higher triglycerides and increased insulin resistance (homeostasis model assessment of insulin resistance) in pregnancy [82,83]

Elsewhere, AI can be used to monitor safety indicators and enhance pharmacovigilance