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Restraints High Cost and Potential Gastrointestinal Side Effects May Restrain Market Growth The relatively high cost of GLP-1 receptor agonists can be a significant restraint on market growth, particularly in regions with limited healthcare access or reimbursement

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Why GLP-3 Hasnt Gained Traction Lack of Clinical Data: Without clear receptors and mechanisms, its challenging to develop therapeutic applications

In fact, some studies in rats have suggested that postprandial rises in (presumably gutderived) active GLP1 are not detectable in the bloodstream beyond the liver, although in humans, postprandial rises in venous GLP1 have been measured (Kreymann et al., 1987