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As body weight decreases, the metabolic demands on the body change, which may affect how much thyroid hormone replacement is needed
13 In the PIONEER-6 study, which compared oral semaglutide to placebo, retinopathy or adverse events related to DR occurred in 7.1% of semaglutide and 6.3% of placebo subjects
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In retinal tissues from the ganglion cell layer, inner nuclear layer, and outer plexiform layer, phosphorylated AKT and ERK1/2 were considerably higher in the DR group than in the normal group

Muranaka MO, Nguyen TH, Wang AT, Cordero J, Yang SJ, Felix J, et al
