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Repeatedly puncturing or using a single container past its expiration date also increases the risk of bacterial contamination, which can cause serious infections

However, this progress has been limited to older adults, as colorectal cancer death rates among those diagnosed before age 50 increased by approximately 14 percent between 1990 and 2023 (4)

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In the SUMMIT trial, tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure in patients with obesity-related HFpEF and also improved health status (Packer et al., 2025)

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