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G., Vrecko, C., Volc, D

Imbalance toward GIP receptor, combined with distinct signaling properties at the GLP-1 receptor, together may account for the promising efficacy of this investigational agent

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In routine clinical practice, our data suggest that this event frequently leads to GLP-1R agonists discontinuation, which may negatively impact patient treatment adherence

It is unknown whether MOUNJARO causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined