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References 1.Mller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschp MH

Cell 167 , 739749 (2016)

Strikingly, CA7S activated TGR5 signalling in human HEK293T cultured cells, increased GLP1 secretion in vivo in mice and reduced plasma levels of glucose after gavage

CrossRef Effect of the Glucagon-Like Peptide-1 Receptor Agonists on Autonomic Function in Subjects with Diabetes: A Systematic Review and Meta-Analysis Carla Greco, Daniele Santi, Giulia Brigante, Chiara Pacchioni, Manuela Simoni Diabetes & Metabolism Journal.2022

GLP-1s like Wegovy and Mounjaro have four mechanisms to improve blood sugar levels and support weight loss: Improve insulin function: Improving insulin response to glucose from meals enables the body to move glucose from the blood and into the cells (like muscle cells) to be burnt for energy or stored as glycogen