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Jen : I can see this

Gaining weight may come from a slower body process, so you burn fewer calories, making it harder to balance what you eat and what you use up

At this concentration, 0.25 mg requires drawing 10 units on your insulin syringe, an amount that is easy to measure accurately

I personally dont love that the odds of these happening are basically 1 in 4 patients, but at the same time over time the rate does decrease with time
doi: 10.1016/j.bmcl.2010.06.059 253 YoshikawaM MurakamiTShimadaH MatsudaH YamaharaJTanabeGet al