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Patient safety advice should include: Reporting severe or persistent abdominal pain immediately Maintaining adequate hydration, particularly during gastrointestinal upset Monitoring for signs of depression or suicidal ideation (regulatory authorities are monitoring this signal, though no causal link has been established) Understanding that rapid weight loss may necessitate adjustment of other medications Regarding pregnancy , advice is product-specific: Wegovy and Saxenda are contraindicated in pregnancy

As of 2024, Colorado had an obesity rate of 25%

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Paoli A., Mancin L., Giacona M.C., Bianco A., Caprio M

Retatrutide is still in phase 3 development, and regulators would need to review full data before any authorisation decision