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Although the SAVOR and EXAMINE studies were delineated to verify cardiovascular safety of two DPP-4i, namely saxagliptin and alogliptin, respectively, both are considered to be the first controlled clinical trials to address the effect of GLP-1 system on CVD

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They bind directly to GLP-1 receptors throughout the body and activate them powerfully and continuously

The weekly injection makes it convenient compared to other medications that require daily dosing

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