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In order to maintain the bile acid pool, therefore, the amount of bile acid excreted is almost equal to the amount newly synthesized by the liver

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We will continue to scrutinise the data to see whether abnormal blood test results such as having pre-diabetes might predict a better response to exenatide, and whether there were more of these people in the earlier, smaller trials in which we found positive overall effects. The trial was supported by the UCL Comprehensive Clinical Trials Unit (UCL CCTU), the National Institute for Health and Care Research (NIHR), UCLH Biomedical Research Centre and the NIHR UCLH Clinical Research Facility

doi: 10.1001/jamanetworkopen.2024.57232

Immune-related adverse events, which were not observed previously, appeared in 4 patients with positive and 2 with negative treatment-emergent antibodies