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developed a balanced GLP-1 agonist/glucagon antagonist, ANC7K2 (structure not shown

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The crystal structure of ligand coupled to GLP-1R and GIPR extracellular domain (19-21), structure-activity relationships of incretins (10, 24, 25), the similarities in their primary sequences as well as the sequence differences in the middle and the C terminal region of the respective agonists, guided us to rationally design the hybrid peptide with potent GLP-1R and GIPR dual activity in a single molecule