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AMPK/SIRT1 induced by semaglutide may also regulate autophagy and mitophagy, increasing transcription factor TFEB and parkin

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Schoretsanitis G, et al

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The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]