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Ethics statement Ethical approval was not required for the studies involving humans because of the nature and design (observational case series)

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In one study, 6-weeks long administration of GLP-1 to type 2 diabetic patients reduced fasting blood glucose and hemoglobin A1c, a measure of long-term sugar control (15)

Blood sugar control (Phase 2 T2D trial) In patients with type 2 diabetes, retatrutide reduced HbA1c by 2.02 percentage points, with 67% of participants reaching normoglycemic levels (HbA1c below 5.7%)

In rodents and humans, there is a progressive decrease in circulating GLP-1 across pregnancy [18,19] which, as with insulin resistance that occurs during pregnancy, would cause increased food intake, decreased glucose storage and facilitate shunting of glucose to the growing fetus