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For patients with a hungry brain, switching to dual agonists such as tirzepatide (commercially known as Mounjaro), which targets two digestive hormones, GLP-1 and glucose-dependent insulinotropic peptide (GIP) may be useful

The initial clinical investigation of tirzepatide shows unprecedented efficacy for glucose lowering and weight loss in T2DM as about 30% of patients receiving the 15 mg dose reached normoglycemia (HbA1C 95% purity at Eli Lilly and Company or obtained from Caslo

For patients, the practical question is simple

Cagrilintide can be used in combination with any of the GLP-1 medications listed above

The bigger and more efficient the engine, the more fuel it burns even when idling