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GLP-1 receptor agonists are administered subcutaneously into the abdomen, thigh, or upper arm with no clinically relevant absorption differences between sites

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Given the overlap in symptoms between HFrEF and HFimpEF, relying solely on physical exams and symptom reviews to evaluate improvements in cardiac function is insufficient to guide treatment decisions

However, none have yet been approved for the treatment of NASH, while many others have already been deemed ineffective (e.g., elafibranor, seladelpar, emricasan, selonsertib and elobixibat)