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A recent randomized study just published in the Lancet in 2025 evaluated 194 folks randomly assigned to Exenatide (n=97) or placebo (n=97)

Furthermore, GLP-1s increase liking and reduce wanting for food based on functional magnetic resonance imaging (fMRI) scans [2], a remarkable result that is reminiscent of a mindfulness practice and one that suggests research is needed into whether a GLP-1 increases mindful eating behaviors based on validated questionnaires, like the Mind-Eat scale [3]

Also, semaglutide is more cost-effective for achieving equivalent weight loss based on the calculated treatment cost

Preconception considerations with GLP-1 receptor agonists

Ozempic is authorised in the USA and UK for the treatment of Type 2 Diabetes, but not as a specific weight loss drug