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- Avexitide is a novel, first-in-class GLP-1 receptor antagonist with the potential to treat hyperinsulinemic hypoglycemia - FDA Breakthrough Therapy Designation granted for avexitide for post-bariatric hypoglycemia (PBH) and congenital hyperinsulinism - Acquisition builds on Amylyx endocrine and neuroscience expertise and aligns with pipeline focus of delivering important potential treatment options to communities with high unmet needs - Phase 3 program for avexitide in PBH expected to begin in Q1 2025, with data readout anticipated in 2026

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Other notable greenlights this year include Bristol Myers Squibbs Cobenfy, the first novel therapeutic for schizophrenia in 35 years, and Madrigal Pharmaceuticals Rezdiffra, the first-ever treatment for MASH.

Payers are known to vary their level of control between different indications for the same drug and between different payer channels, and the GLP-1 market is no exception

A study conducted at Harvard University has identified the central role of serotonin - a hormone involved in mood regulation - in the development of post-bariatric hypoglycaemia."We identified that this type of hypoglycaemia is associated with the dysregulation of serotonin levels in the blood, a hormone that, in addition to controlling mood, is also capable of stimulating the secretion of the hormones insulin and GLP-1 in the body," explained Rafael Ferraz-Bannitz, who conducted the research du