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Description
Bone marrow chimeras were generated by lethally irradiating Dpp4 EC+/+ (pool of Dpp4 fl/fl and Tie2 -Cre mice) and Dpp4 EC/ mice (1100 cGy split into 2 equal doses 4 hours apart), followed by reconstitution with 5 10 6 bone marrow cells from donor B6.SJL-Ptprc a Pepc b /BoyJ mice as described previously (56)
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Intact and total AMG 133 exposures more closely approximate each other in the initial phase of the study than in the terminal phase (Fig
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For most patients, it is temporary
