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NICE recommends GLP-1 receptor agonists for type 2 diabetes when metformin and other oral medications fail to achieve adequate glycaemic control, particularly with BMI 35 kg/m or weight-related comorbidities

For instance, people who experience accelerated aging of the heart face a 250% increased risk of developing heart failure

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Jankowski J, Floege J, Fliser D, Bohm M, Marx N

Acta Cardiol 78(5):552564 Mahapatra MK, Karuppasamy M, Sahoo BM (2022) Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes

Available case reports demonstrate plausibility, but large observational studies are needed to estimate actual risk