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Description
Unlike GLP-1, exendin-4 has a glycine at the second amino acid position at the N-terminus, which protects the peptide from DPP-4-mediated degradation and inactivation
The mechanism of incretin action is schematized in the figure below
A summary of clinical trials to include drug, dosing strategy, sample size, primary outcome measurements, risk reduction, date of publication, and conclusions is found in Table 1 [103112]
Das SR, Everett B, Birtcher KK, et al
thereafter, remain at 7mg or escalate to 14mg if needed
