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"Retatrutide, a GIP, GLP-1, and glucagon receptor agonist for obesity: A phase 2 trial." New England Journal of Medicine , 389(6), 514-526
The part of the brain they target is involved in regulating both hunger and thirst
Additional benefits include improved metabolic health factors like blood sugar, blood pressure, and cholesterol, as well as reduced inflammatory markers
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Challenges such as solubility limitations and non-specific binding must be carefully managed
