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According to the transdiagnostic theory of eating disorders, dietary restriction and restraint are key behavioral expressions and maintaining mechanisms of eating disorders psychopathology (Fairburn et al., 2003)

Exogenous leptin administration is associated with a suppression of food intake, a reduction in body weight, and an upregulation of uncoupling protein 1 (UCP1) expression in adipose tissue depots, all of which have been suggested to require a fully functioning histaminergic system (79, 80, 92, 133)

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Clonal HEK293 cells stably expressing either untagged human GIPR or human GLP-1R at various levels of receptor density were used for measurement of cAMP accumulation using the Gs Dynamic Assay and homogenous time-resolved fluorescence (62AM4PEJ, PerkinElmer)

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