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However, these effects are relatively small compared with other pharmacologic treatments for obesity, such as GLP-1 receptor agonists (e.g., semaglutide), which produce greater and more sustained weight loss and improvements in glycemic control

This doesnt make it inferior per se, but it does mean that the former can increase energy expenditure in addition to decreasing food intake

Like discontinuation of blood pressure lowering medication, once anti-obesity medications are stopped, then metabolic adaptation is no longer opposed and therefore weight regain occurs, Dr Rigas says.

[DOI] [PubMed] [Google Scholar] 42.Bertoni AG, Hundley WG, Massing MW, Bonds DE, Burke GL, Goff DC., Jr Heart failure prevalence, incidence, and mortality in the elderly with diabetes