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This prolonged exposure ensures continuous activation of GLP-1R, improving fasting and postprandial glucose control compared to short-acting agonists (like exenatide) [67]

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Despite this difference, GLP-1 therapies should only be considered lifelong therapies where indicated (e.g., cardiovascular disease risk reduction), as the addition of GLP-1s triples baseline per user annual pharmacy expenditures regardless of adherence status, erasing any medical cost savings