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When the balance of your gut bacteria shifts, it can either help your body adapt smoothly or set the stage for prolonged digestive dysfunction
Whereas the DPP-IV degradation can be avoided by substituting Ala 8 with various amino acids like Gly, Ser, d-Ala, and Aib, 32,37 the degradation by NEP 24.11 is hard to address in a similar manner because of the multiple sites that NEP 24.11 targets (Figure 1)
16 Ludvik, B., et al., Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial
Winther JB, Holst JJ
Verstoorde darmflora: De aanmaak van GLP-1 vindt plaats in de darm
