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Learn how GLP-1 receptor agonists help patients with type 2 diabetes and obesity manage blood sugar, lose weight, and protect heart health.

Public Citizen contends that Novo Nordisk and Eli Lilly's obesity drugs are straining budgets so much that generics should be authorized.

However, heterogeneous experimental designs and limited translational data necessitate further standardized and in vivo research to define clinical applications.

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Methods We obtained the data from PubMed, Scopus, Embase, and Web of Science for all eligible studies, including clinical trials (RCT) and cohorts comparing GLP-1 RAs to placebo or other hypoglycemic agents in patients with HFpEF published until December 31st, 2024