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Loss of insulin-like growth factor-1 signaling in astrocytes disrupts glutamate handling
Change in albuminuria and GFR as end points for clinical trials in early stages of CKD: a scientific workshop sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency

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The rationale extends beyond simple formulation chemistry into the realm of NAD+ precursor biology, mitochondrial function, and adipose tissue metabolism
