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Older adults with type 2 diabetes: a Target Trial Emulation Study

Weight regain after discontinuation is common, with studies showing 60-70% of lost weight returning within a year of stopping

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Limited Long-term Data : While short- to medium-term data are compelling, the long-term safety and efficacy profile over decades of treatment remains incompletely characterized

We have: good short- and medium-term data improving cardiovascular outcome data But we do not yet have decades of long-term weight-loss population data