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The most common side effects include: Insomnia: The number one complaint
Discontinuation often leads to weight regain, making long-term maintenance challenging

More common with aging, sun damage, or frequent rubbing

[DOI] [PubMed] [Google Scholar] [238].Behbehani R, Mabrook A, Abbas JM, Al-Rammah T, Mojiminiyi O, Doi SA (2010)

28 This rapid increase in cAMP activates two key signaling molecules: protein kinase A (PKA) and exchange protein activated by cAMP-2 (Epac2)
