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We're talking studies with hundreds of thousands of people, some cases over a million, that point to something I think most people who lived, us, I hope, or if you just came across this podcast, you're going to be motivated to do that, have never really thought too much about

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Consider this scenario: a patient starts semaglutide with triglycerides at 320 milligrams per deciliter alongside a BMI of 36 and insulin resistance

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Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation