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2026 Apr 1

From the nationwide prospective cohort study, we found that the administration of GLP-1 RAs was associated with a significantly decreased risk of DR, which showed robustness in different sensitivity analyses

Women of childbearing potential taking an oral hormonal contraceptive should add a barrier contraceptive for 4 weeks after starting tirzepatide and after each dose escalation

About a 20% reduction in daily calorie intake

Clinical studies, including the STEP 1 extension trial with semaglutide, have demonstrated that patients often regain a significant portion of the weight they lost whilst on treatment, sometimes within several months of discontinuation