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WYRGRL modification enhanced targeted delivery and retention of GLP-1RAs@NPs in cartilage In this study, RBITC was used to label GLP-1RAs@NPs and GLP-1RAs@NPs-WYRGRL, and the targeting ability of RBITC-GLP-1RAs@NPs and RBITC-GLP-1RAs@NPs-WYRGRL toward chondrocytes and articular cartilage in vivo and in vitro was observed through fluorescence staining (Fig

40 A dose-dependent pattern of body-weight reduction was observed, with the patients receiving the maximum dose of 0.4mg per day achieving a mean 13% weight loss, while the Placebo group exhibited a mean loss of 1%

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