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Dulaglutide (Trulicity) Strengths: Once-weekly dosing Easy-to-use auto-injector device Proven cardiovascular benefit Good tolerability profile Considerations: Less weight loss than semaglutide Moderate (not maximum) glucose efficacy Best for: Patients prioritizing convenience and tolerability over maximum efficacy

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For long-term success, they should be combined with: Nutrition counseling to support a sustainable dietary pattern Exercise and physical therapy to strengthen the back and core Behavioral coaching to build lasting habits Additionally, patients should avoid the temptation of using GLP-1 medications as a quick fix or without medical supervision
