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Description

These medications are administered via subcutaneous injection, with dosing gradually increased to minimise gastrointestinal side effects

In line with this expectation, GLP-1R agonists, including exendin-4, have been shown to exhibit antidepressant properties, independently of weight loss, in preclinical studies (95-97)

aRWD: real-world data from cohort or registry studies (electronic health records, insurance-claims databases), bSRS: adverse drug reaction evidence from case reports and spontaneous-reporting systems, such as the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and World Health Organization (WHO) VigiBase