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*Correspondence: Fenglei Zhang [email protected] Yan [email protected] Xu [email protected] This article was submitted to Heart Failure and Transplantation, a section of the journal Frontiers in Cardiovascular Medicine These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)

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