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(Reuters) Known risk factors for NAION include: Diabetes High blood pressure High cholesterol Sleep apnea Smoking Medications that affect blood flow or circulation Because GLP-1 drugs influence metabolic function, blood sugar levels, and physiological processes that may affect circulation, plaintiffs in GLP-1 lawsuits allege that drug manufacturers knew or should have known about the potential risk of optic nerve damage and failed to adequately warn patients and healthcare providers

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14,15 The second step is the use of pharmacologic medications, including metformin, oral sulphonylureas, oral sodium-glucose cotransporter 2 (SGLT2) inhibitors, oral dipeptidyl peptidase 4 (DPP-4) inhibitors, oral -Glucosidase, injectable glucagon-like peptide 1 (GLP1) receptor agonists, or injectable insulin

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Key Findings: No significant difference in overall adverse events between the two drugs Tirzepatide increased treatment discontinuation by 32% a crucial real-world consideration Better glycemic control (HbA1c targets) with tirzepatide, especially in early-stage disease Efficacy vs tolerability trade-off remains central to treatment decisions Clinical Insight: While tirzepatide offers strong metabolic benefits, our analysis highlights a critical reality: A treatment is only effective if patients can tolerate and continue it