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High levels of IL-1 have been reported in freshly homogenized colonic biopsies taken from IBD patients

97,98 Therefore, it has the effect of both anti-obesity, and anti-oxidant to improve BBB permeability

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This treatment approach of considering cardiorenal protection even in early disease stages had already been proposed by the American College of Cardiology in 2019 and has since been included in new updates of various Spanish consensus documents [10,11,12]

So those are some things that researchers are concerned about