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Yesweight loss of 15-20% achieved through semaglutide typically reduces inflammatory markers CRP and TNF-alpha by 10-30%, which may indirectly benefit lupus disease control

The limited number of patients using Mounjaro off-label for obesity is roughly on par with Ozempic persistence for type II diabetes, hovering around 45% at month 12

GPR43 is distributed in adipose tissue, bone marrow, spleen, pancreas, peripheral blood mononuclear cells, small intestine, and mammary gland, while GPR41 is distributed in various tissues, especially in immune cells

Brenna et al., 2016)