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In a systematic review of 55 double-blinded, placebo-controlled randomized clinical trials, GLP-1RA treatment was associated with an increased risk of cholelithiasis compared with placebo (RR 1.46, 95% CI 1.091.97) but not cholecystitis, cholangitis, or pancreatitis (63)

[4] [6] This leads to reduced calorie intake over time

For patients currently using Wegovy or considering it as a treatment option, this development raises important questions about who might benefit

Sources Phase 2 trial (NEJM) New England Journal of Medicine TRIUMPH-4 results Eli Lilly Investor Relations JAMA coverage of Phase 2 results JAMA Related reading Retatrutide Phase 3 Trials 2026: TRIUMPH & TRANSCEND-T2D Tracker Living tracker of every retatrutide trial TRIUMPH-1/3/4/5, TRIUMPH-Outcomes, TRANSCEND-T2D-1/2, and SYNERGY-OUTCOMES Phase 3 readouts

This is why the conversation about how long retatrutide lasts extends far beyond pharmacokinetics into questions about long-term treatment strategy