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Trials adopting this multimodal design should integrate stratification by vagal tone and metabolic phenotype, allowing for precision targeting of treatment and minimizing unnecessary drug exposure in low responders

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Evidence for estradiols interaction with CCK comes from studies of ovariectomized rats

\n\nHowever, the technological frontier, validated by historic FDA and EMA approvals, has introduced a total paradigm shift with the arrival of gliflozins and non-steroidal mineralocorticoid antagonists