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This assessment should include a detailed history of symptom onset, frequency, severity, and relationship to medication initiation or dose changes

Medically unsupervised use can have serious health complications
A run of biomarker-positive, outcome-negative results still leaves sponsors needing well-characterized CSF to chase the mechanism
Soft drink manufacturers and breweries may experience an impact if this trend continues
In addition to complex medication regimens, other behavioural modification is also needed