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Possible side effects of orlistat (Xenical/Alli) While the active ingredient orlistat which works by inhibiting the enzymes that break down fat in the gut, preventing your body from absorbing it debuted back in 1999 to a lot of fanfare, Fishman says its become less popular for two big reasons: side effects and minimal benefits. Those side effects are mostly gastrointestinal, and can include abdominal pain in up to 30% of patients

The estimated mean weight loss was 7.03 kg in the placebo group, 11.19 kg in the exercise group, 13.74 kg in the liraglutide group, and 16.88 kg in the combination group

A recent publication by Jones et al

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