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Retatrutide (LY3437943) is a triple receptor agonist acting on the GLP-1, GIP, and glucagon receptors, studied in metabolic and obesity research for its effects on energy expenditure, glucose regulation and body composition

Patients receiving oral semaglutide had significantly higher risk of treatment discontinuation due to side effects (RR: 1.79, 95% CI: 1.13 to 2.83)

A small number report new or increased feelings of depression or anxiety, making it crucial to monitor for any changes in mental health while on these medications

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

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