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Application of liraglutide reduced mitochondrial damage by attenuating mitophagy via the protein phosphatase and tensin homolog-induced kinase 1 (PINK1)/Parkin pathway, the most well-known pathway for mitophagy (Figure 3)

Medical Writing and Editorial Assistance Christopher Williams (Novo Nordisk A/S) and Angela Stocks (Larix A/S, Copenhagen, Denmark) provided medical writing and editorial assistance in the preparation of this article, which was funded by Novo Nordisk

Certain genetic variants in appetite-regulating pathwayssuch as FTO rs9939609, MC4R rs17782313, and GLP1R rs6923761directly influence how your body responds to hunger signals and metabolic adaptation

Its intended for use in combination with exercise and a reduced-calorie diet

Type 2 diabetes is a complex disease, but with the unique clinical profile of Ozempic, we believe it has the potential to set a new standard for the treatment of the disease. In March 2022, Ozempic 2 mg dose was approved by the US FDA to improve blood sugar in adults with type 2 diabetes and to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes and known heart disease