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Metabolic therapies such as GLP-1s primarily influence inflammation, mitochondrial function, and nutrient signaling, while other pharmacological or lifestyle strategies may act on telomere maintenance [16], senescence biology [17], or epigenetic regulation [18]
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Conversely, higher GLP1R expression correlates with poorer survival outcomes in cancers such as cervical squamous cell carcinoma, lung squamous cell carcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma

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