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Description
Mass spectrometery was performed on a Q-Exactive HF Orbitrap mass spectrometer (ThermoFisher Scientific)

It has been hypothesized that the effects of GLP-1R agonists to reduce energy intake are at least partially driven by nausea and other GI AEs

High Amylase Levels May Indicate: Pancreatitis (acute or chronic) Pancreatic duct blockage Gallbladder inflammation Perforated ulcers or intestinal obstruction Low Amylase Levels May Indicate: Pancreatic damage or failure Liver disease or cystic fibrosis Clinical Insight: While amylase is a valuable indicator, its often interpreted alongside lipase levels for greater diagnostic accuracy, since lipase remains elevated longer in pancreatic disorders

It is unclear why directionality would vary between studies, although we note these studies were performed in specific disease contexts, and are in substantially smaller samples
Elemam NM, Hannawi S, Maghazachi AA
