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Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)

This showed us that GLP-1 and GIP are not as effective in shutting down glucagon and stimulating insulin secretion in patients with kidney disease compared to controls, suggesting increased resistance to their action in CKD, Ahmadi added

Understanding GLP-1 Medications: From Diabetes Treatment to Weight Loss Revolution

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Systematic investigation is needed to identify which agents, if any, are best suited for ophthalmic applications, paving the way for a precision medicine approach