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Risk Factors for Mood Changes During GLP-1 Therapy Patients with a personal or family history of depression, anxiety, or bipolar disorder may face higher risk of mood destabilization during semaglutide treatment

Transitioning between medications can sometimes cause temporary discomfort so always consult your doctor if anything unusual occurs during your treatment plan

Doherty, University College Dublin, Ireland Reviewed by Jonathan Soldera, University of Caxias do Sul, Brazil Agnese Favale, University of Cagliari, Italy Updates Copyright 2026 Lee, Bajgain and Lightner

Losing muscle not only impacts strength and energy but can also slow metabolism, making long-term weight maintenance more challenging

"I'm in the gym now six days a week," she said